Mutagenesis in Medicine
Early Cancer Institute, University of Cambridge

Alexander Ross

Academic Clinical Fellow

Alexander is an honorary specialty registrar in Clinical Genetics and a post-doctoral researcher funded by the NIHR. During his PhD Alexander explored the development of the human liver and intestine at single-cell resolution and developed the first stem cell based liver organoid model, which offers great promise as a tool to study the liver in health and disease.

 

 Key qualifications:

Wellcome Translational Medicine PhD Programme for Clinicians, University of Cambridge, 2019

Medicine, Imperial College London, 2012 (Triple Distinction)

BSc Molecular Medicine, University College London 2010 (1st Class Hons, Dean’s List)

First author publications:

Brandon T. Wesley*, Alexander D. B. Ross*, Daniele Muraro, Zhichao Miao, Sarah Saxton, Rute A. Tomaz, Carola M. Morell, Katherine Ridley, Ekaterini D. Zacharis, Sandra Petrus-Reurer, Judith Kraiczy, Krishnaa T. Mahbubani, Stephanie Brown, Jose Garcia-Bernardo, Clara Alsinet, Daniel Gaffney, Olivia C. Tysoe, Rachel A. Botting, Emily Stephenson, Dorin-Mirel Popescu, Sonya MacParland, Gary Bader, Ian D. McGilvray, Daniel Ortmann, Fotios Sampaziotis, Kourosh Saeb-Parsy, Muzlifah Haniffa, Kelly R. Stevens, Matthias Zilbauer, Sarah A. Teichmann, Ludovic Vallier. Single-cell atlas of human liver development reveals pathways directing hepatic cell fates. Nature Cell Biology.  Sep 2022 . *co-first author

Alexander D B Ross, Matthias Zilbauer.  Validation of IBD-associated Whole-blood DNA Methylation Changes-Where Do We Go From Here? J Crohns Colitis. Oct 2022.

Ross ADB, Perrone F, Elmentaite R, Teichmann SA, Zilbauer M. Obtaining purified human intestinal epithelia for single-cell analysis and organoid culture. STAR Protoc. 2021.

Rasa Elmentaite*, Alexander Ross*, Kenny Roberts, Kylie R. James, Daniel Ortmann, Tomas Gomes, Komal Nayak, Liz Tuck, Sophie Pritchard, Omer Ali Bayraktar, Robert Heuschkel, Ludovic Vallier, Sarah A. Teichmann and Matthias Zilbauer

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohn’s disease. Developmental Cell. Dec 2020 *co-first author

Judith Kraiczy∗, Alexander D.B. Ross∗, Jessica L. Forbester, Gordon Dougan, Ludovic Vallier, Matthias Zilbauer. Genome-wide epigenetic and transcriptomic characterization of human induced pluripotent stem cell-derived intestinal epithelial organoids. CMGH. Oct 2018. *co-first author

Ross A, Shelley H, Novell K, Ingham E, Callan J, Heuschkel R, Morris MA, Zilbauer M. Assessing quality outcome measures in children with coeliac disease-experience from two UK centres. Nutrients, 2013. 5(11), pp.4605–4613

CO-AUTHOR PUBLICATIONS

Vincent R. Knight-Schrijver, Hongorzul Davaapil, Semih Bayraktar, Alexander D. B. Ross, Kazumasa Kanemaru, James Cranley, Monika Dabrowska, Minal Patel, Krzysztof Polanski, Xiaoling He, Ludovic Vallier, Sarah Teichmann, Laure Gambardella, and Sanjay Sinha. A single-cell comparison of adult and embryonic human epicardium defines the age-associated changes in epicardial activity. Nature Cardiovascular Research. Dec 2022.

Rimland CA, Tilson SG, Morell CM, Tomaz RA, Lu WY, Adams SE, Georgakopoulos N, Otaizo-Carrasquero F, Myers TG, Ferdinand JR, Gieseck RL 3rd, Sampaziotis F, Tysoe OC, Ross A, …, Hannan NRF, Forbes SJ, Saeb-Parsy K, Wynn TA, Vallier L. Regional Differences in Human Biliary Tissues and Corresponding In Vitro-Derived Organoids. Hepatology. Jan 2021.

Beumer J, Puschhof J, Bauzá-Martinez J, Martínez-Silgado A, Elmentaite R, James KR, Ross A, Hendriks D, … Snippert H, Zilbauer M, Teichmann SA, Wu W, Clevers H. High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells. Cell. Aug 2020.

M Gasparetto, F Payne, K Nayak, J Kraiczy, C Glemas, Y Philip-McKenzie, A Ross, R D Edgar, D R Zerbino, C Salvestrini, F Torrente, N T Ventham, R Kalla, J Satsangi, P Sarkies, R Heuschkel, M Zilbauer. Transcription and DNA Methylation patterns of blood derived CD8 + T cells are associated with age and Inflammatory Bowel Disease but do not predict prognosis. Gastroenterology. Aug 2020.

Yiangou L, Ross ADB, Goh KJ, Vallier L. Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications. Cell Stem Cell. Apr 2018.

Howell KJ, Kraiczy J, Nayak KM, Gasparetto M, Ross A, Lee C, Mak TN, Koo BK, Kumar N, Lawley T, Sinha A, Rosenstiel P, Heuschkel R, Stegle O, Zilbauer M. DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology. Feb 2018.

Kraiczy J, Nayak K, Howell K, Ross A, Forbester J, Salvestrini C, Mustata R, Perkins S, Andersson-Rolf A, Leenen E, Liebert A, Vallier L, Rosenstiel P, Stegle O, Dougan G, Heuschkel R, Koo B-K, Zilbauer M. DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development Gut. Nov 2017.

Sampaziotis F, Justin A, Tysoe OC, Sawiak S, Godfrey E, Upponi SS, Gieseck RL, Cardoso de Brito M, Lie Berntsen N, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, … Vallier L. Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine. Jul 2017.

Gasparetto M, Guariso G, Visona L, Pozza D, Ross A, Heuschkel R, Zilbauer M. Clinical course and outcomes of diagnosing Inflammatory Bowel Disease in children 10 years and under: retrospective cohort study from two tertiary centres in the United Kingdom and in Italy. BMC Gastroenterology. Mar 2016. 16:35.

Wahid AM, Devarajan K, Ross A, Zilbauer M, Heuschkel R. Paediatric gastrointestinal endoscopy: a qualitative study. Eur J Gastroenterol Hepatol. Jan 2016 28(1) 25-9

Kraiczy J, Nayak K, Ross A, Raine T, Nam Mak T, Gasparetto M, Cario E, Rakyan V, Heuschkel R, Zilbauer M. Assessing DNA methylation in the developing human intestinal epithelium. Mucosal Immunology 2015 9, 647–658

Atherton R, Ross A, Jessop F, Williams R, Heuschkel R, Zilbauer M. Coeliac Disease in Children with Type 1Diabetes: Are Current Guidelines Proving Difficult to Implement in Practice? JPGN, 2014. 54(1), pp.136–160.

 

Contact Us

Dr. Serena Nik-Zainal
Early Cancer Institute
University of Cambridge
Hutchison Research Centre
Box 197
Cambridge Biomedical Campus
Cambridge
United Kingdom
CB2 0XZ

sn206@cam.ac.uk